Development and validation of a stability indicating RP-HPLC method for simultaneous estimation of Olmesartan Medoxomil and Metoprolol Succinate in pharmaceutical dosage form

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Development and validation of a stability indicating RP-HPLC method for simultaneous estimation of Olmesartan Medoxomil and Metoprolol Succinate in pharmaceutical dosage form

AIM AND BACKGROUND A simple, rapid, precise and isocratic RP-HPLC (Reverse Phase High Performance Liquid Chromatography) method is aimed to develop for the simultaneous estimation of Olmesartan Medoxomil and Metoprolol Succinate in bulk drug and pharmaceutical dosage form. MATERIALS AND METHODS The quantification is carried out using YMC-Pack CN (250 × 4.6 mm, 5.0 μm) column and the mobile ph...

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Stability Indicating RP-HPLC Method Development and Validation for the Estimation of Sumatriptan in Bulk and Pharmaceutical Dosage Form

Article history: Received on: 31/01/2016 Revised on: 16/03/2016 Accepted on: 14/04/2016 Available online: 28/06/2016 A simple, highly sensitive stability indicating reverse phase high-performance liquid chromatographic (RPHPLC) method was developed and validated for the determination of sumatriptan succinate in bulk and tablet dosage form. The analysis was performed on reverse phase C18 ODS Ine...

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Stability Indicating Rp-hplc Method for the Simultaneous Determination of Olmesartan Medoxomil and Atorvastatin Calcium

A simple, rapid, and precise, stability indicating RP-HPLC method for simultaneous analysis of olmesartan medoxomil (OLM) and Atorvastatin (ATR) in bulk has been developed and validated. The analytes were separated by using a Waters symmetry C18 analytical column (250mm × 4.6mm, 5 μm) with a mobile phase consisting of Acetonitrile and 0.02 M potassium dihydrogen phosphate buffer containing 0.1%...

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The present study describes a simple, accurate, precise and cost effective UV-Vis Spectroscopic and RP-HPLC method for the estimation of Ibandronate sodium (IBN). The determination of Ibandronate sodium (IBN) was performed by both UV and RP-HPLC method using 215 nm as the determination wavelength. The drug was dissolved in NaOH solution (0.1N NaOH) for estimation in UV and in distilled water fo...

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ژورنال

عنوان ژورنال: Pharmaceutical Methods

سال: 2012

ISSN: 2229-4708

DOI: 10.4103/2229-4708.103880